SrasV1, Main, Exploration, bibRecord, 006038

Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality

Identifieur interne : 006038 ( Main/Exploration ); précédent : 006037; suivant : 006039

Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality

Auteurs : Owen Tak-Yin Tsang [Hong Kong] ; Tai-Nin Chau [Hong Kong] ; Kin-Wing Choi [Hong Kong] ; Eugene Yuk-Keung Tso [Hong Kong] ; Wilina Lim [Hong Kong] ; Ming-Chi Chiu [Hong Kong] ; Wing-Lok Tong [Hong Kong] ; Po-Oi Lee [Hong Kong] ; Bosco Hoi Shiu Lam [Hong Kong] ; Tak-Keung Ng [Hong Kong] ; Jak-Yiu Lai [Hong Kong] ; Wai-Cho Yu [Hong Kong] ; Sik-To Lai [Hong Kong]

Source :

Emerging Infectious Diseases [ 1080-6040 ] ; 2003.

RBID : PMC:3035547

Descripteurs français

KwdFr :
- Adulte, Coronavirus (isolement et purification), Coronavirus (pathogénicité), Femelle, Hong Kong (épidémiologie), Humains, Maladies transmissibles émergentes (mortalité), Maladies transmissibles émergentes (physiopathologie), Maladies transmissibles émergentes (virologie), Muqueuse nasale (virologie), Mâle, RT-PCR, Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Valeur prédictive des tests.
MESH :
- isolement et purification : Coronavirus.
- mortalité : Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- pathogénicité : Coronavirus.
- physiopathologie : Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- virologie : Maladies transmissibles émergentes, Muqueuse nasale, Syndrome respiratoire aigu sévère.
- épidémiologie : Hong Kong.
- Adulte, Femelle, Humains, Mâle, RT-PCR, Valeur prédictive des tests.
Wicri :
- geographic : Hong Kong.

English descriptors

KwdEn :
- Adult, Communicable Diseases, Emerging (mortality), Communicable Diseases, Emerging (physiopathology), Communicable Diseases, Emerging (virology), Coronavirus (isolation & purification), Coronavirus (pathogenicity), Female, Hong Kong (epidemiology), Humans, Male, Nasal Mucosa (virology), Predictive Value of Tests, Reverse Transcriptase Polymerase Chain Reaction, Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology).
MESH :
- geographic , epidemiology : Hong Kong.
- isolation & purification : Coronavirus.
- mortality : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- pathogenicity : Coronavirus.
- physiopathology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- virology : Communicable Diseases, Emerging, Nasal Mucosa, Severe Acute Respiratory Syndrome.
- Adult, Female, Humans, Male, Predictive Value of Tests, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

Severe acute respiratory syndrome (SARS) has caused a major epidemic worldwide. A novel coronavirus is deemed to be the causative agent. Early diagnosis can be made with reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate samples. We compared symptoms of 156 SARS-positive and 62 SARS-negative patients in Hong Kong; SARS was confirmed by RT-PCR. The RT-PCR–positive patients had significantly more shortness of breath, a lower lymphocyte count, and a lower lactate dehydrogenase level; they were also more likely to have bilateral and multifocal chest radiograph involvement, to be admitted to intensive care, to need mechanical ventilation, and to have higher mortality rates. By multivariate analysis, positive RT-PCR on nasopharyngeal aspirate samples was an independent predictor of death within 30 days.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035547

DOI: 10.3201/eid0911.030400
PubMed: 14718079
PubMed Central: 3035547

Affiliations:

Hong Kong

Le document en format XML

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<term>Communicable Diseases, Emerging (mortality)</term>
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<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) has caused a major epidemic worldwide. A novel coronavirus is deemed to be the causative agent. Early diagnosis can be made with reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate samples. We compared symptoms of 156 SARS-positive and 62 SARS-negative patients in Hong Kong; SARS was confirmed by RT-PCR. The RT-PCR–positive patients had significantly more shortness of breath, a lower lymphocyte count, and a lower lactate dehydrogenase level; they were also more likely to have bilateral and multifocal chest radiograph involvement, to be admitted to intensive care, to need mechanical ventilation, and to have higher mortality rates. By multivariate analysis, positive RT-PCR on nasopharyngeal aspirate samples was an independent predictor of death within 30 days.</p>
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<name sortKey="Choi, Kin Wing" sort="Choi, Kin Wing" uniqKey="Choi K" first="Kin-Wing" last="Choi">Kin-Wing Choi</name>
<name sortKey="Lai, Jak Yiu" sort="Lai, Jak Yiu" uniqKey="Lai J" first="Jak-Yiu" last="Lai">Jak-Yiu Lai</name>
<name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name>
<name sortKey="Lam, Bosco Hoi Shiu" sort="Lam, Bosco Hoi Shiu" uniqKey="Lam B" first="Bosco Hoi Shiu" last="Lam">Bosco Hoi Shiu Lam</name>
<name sortKey="Lee, Po Oi" sort="Lee, Po Oi" uniqKey="Lee P" first="Po-Oi" last="Lee">Po-Oi Lee</name>
<name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name>
<name sortKey="Ng, Tak Keung" sort="Ng, Tak Keung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name>
<name sortKey="Tong, Wing Lok" sort="Tong, Wing Lok" uniqKey="Tong W" first="Wing-Lok" last="Tong">Wing-Lok Tong</name>
<name sortKey="Tso, Eugene Yuk Keung" sort="Tso, Eugene Yuk Keung" uniqKey="Tso E" first="Eugene Yuk-Keung" last="Tso">Eugene Yuk-Keung Tso</name>
<name sortKey="Yu, Wai Cho" sort="Yu, Wai Cho" uniqKey="Yu W" first="Wai-Cho" last="Yu">Wai-Cho Yu</name>
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   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3035547
   |texte=   Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:14718079" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality

Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality

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	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.